Nagasaki U Link
Nagasaki University Graduate School of Biomedical Sciences 長崎大学学院医歯薬学総合研究科
 

Publications List

<2017>

  1. Yamamoto T, Oshima Y, Ishikawa T, Mishima H, Matsusue A, Umehara T, Murase T, Abe Y, Kubo SI, Yoshiura KI, Makita N, Ikematsu K. Postmortem genetic analysis of sudden unexpected death in infancy: neonatal genetic screening may enable the prevention of sudden infant death. J. Hum. Genet. (2017) (in press). (pdf)
  2. Seki A, Ishikawa T, Daumy X, Mishima H, Barc J, Sasaki R, Nishii K, Saito K, Urano M, Ohno S, Otsuki S, Kimoto H, Baruteau A, Thollet A, Fouchard S, Bonnaud S, Parent P, Shibata Y, Perrin J.P, Le Marec H, Hagiwara N, Mercier S, Horie M, Probst V, Yoshiura K.I, Redon R, Schott J.J, Makita N. Progressive atrial conduction system defects associated with bone malformation caused by a connexin45 mutation. J Am Coll Cardiol 70(3), 358-70 (2017). doi:10.1016/j.jacc.2017.05.039. (pdf)
  3. Ishikawa T, Makita N, Aoki H, Saida Y. Letter to the Editor J Vet Intern Med(2017) 31(4):967-968.(2017). doi:10.1111/jvim.14781. (pdf)
  4. Yamamoto Y, Makiyama T, Harita T, Sasaki K, Wuriyanghai Y, Hayano M, Nishiuchi S, Kohjitani H, Hirose S, Chen J, Yokoi F, Ishikawa T, Ohno S, Chonabayashi K, Motomura H, Yoshida Y, Horie M, Makita N, Kimura T. Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation. Hum Mol Genet 29(9), 1670-1677 (2017). doi:10.1093/hmg/ddx073. (pdf)
  5. Yamagata K, Horie M, Aiba T, Ogawa S, Aizawa Y, Ohe T, Yamagishi M, Makita N, Sakurada H, Tanaka T, Shimizu A, Hagiwara N, Kishi R, Nakano Y, Takagi M, Makiyama T, Ohno S, Fukuda K, Watanabe H, Morita H, Hayashi K, Fukushima-Kusano K, Kamakura S, Yasuda S, Ogawa H, Y. M, Kapplinger J, Ackerman M, Shimizu W. Genotype-phenotype correlation of SCN5A mutation for clinical and electrocardiographic characteristics of probands with Brugada syndrome: A Japanese multicenter registry. Circulation 135(23), 2255-2270 (2017). doi:10.1161/CIRCULATIONAHA.117.027983. (pdf)
  6. Takahashi K, Ishikawa T, Makita N, Takefuta K, Nabeshima T, Nakayashiro M. A novel de novo calmodulin mutation in a 6-year-old boy who experienced an aborted cardiac arrest. HeartRhythm Case Reports 3, 69-72 (2017). doi:10.1016/j.hrcr.2016.09.004(2017) (pdf)
  7. Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Hattori T, Ohno S, Kodaira M, Suzuki T, Hashimoto H, Okata S, Tanaka A, Aizawa Y, Murata M, Aiba T, Makita N, Furukawa T, Shimizu W, Kodama I, Ogawa S, Kokubun N, Horigome H, Horie M, Kamiya K, Fukuda K. Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochemistry and Biophysics Reports 9, 245-256 (2017). doi:10.1016/j.bbrep.2017.01.002 (pdf)
  8. Ishikawa T, Ohno S, Murakami T, Yoshida K, Mishima H, Fukuoka T, Kimoto H, Sakamoto R, Ohkusa T, Aiba T, Nogami A, Sumitomo N, Shimizu W, Yoshiura KI, Horigome H, Horie M, Makita N. Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction. Heart Rhythm 14(5), 717-724 (2017). doi:10.1016/j.hrthm.2017.01.020 (pdf)
  9. Hu D, Li Y, Zhang J, Pfeiffer R, Gollob MH, Healey J, Harrell DT, Makita N, Abe H, Sun Y, Guo J, Zhang L, Yan G, Mah D, Walsh EP, Leopold HB, Giustetto C, Gaita F, Zienciuk-Krajka A, Mazzanti A, Priori SG, Antzelevitch C, Barajas-Martinez H. The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome. JACC: Clinical Electrophysiology 320 (2017). doi:10.1016/j.jacep.2016.11.013 (pdf)

<2016>

  1. Okata S, Yuasa S, Suzuki T, Ito S, Makita N, Yoshida T, Lin M, Kurokawa J, Seki T, Egashira T, Aizawa Y, Kodaira M, Motoda C, Yozu G, Shimojima M, Hayashiji N, Hashimoto H, Kuroda Y, Tanaka A, Murata M, Aiba T, Shimizu W, Horie M, Kamiya K, Furukawa T,Fukuda K. Embryonic type Na+ channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome. Scientific Reports 6, 34198 (2016). doi:10.1038/srep34198, (pdf)
  2. Yagihara N, Watanabe H, Barnett P, Duboscq-Bidot L, Thomas AC, Yang P, Ohno S, Hasegawa K, Kuwano R, Chatel S, Redon R, Schott J, Probst V, Koopmann TT, Bezzina CR, Wilde AAM, Nakano Y, Aiba T, Miyamoto Y, Kamakura S, Darbar D, Donahue B, Shigemizu D, Tanaka T, Tsunoda T, Suda M, Sato A, Minamino T, Endo N, Shimizu W, Horie M, Roden D,Makita N. Variants in the SCN5A promoter associated with various arrhythmia phenotypes. J Am Heart Assoc 5,e003644,(2016) (pdf)
  3. Ishikawa T, Tsuji Y,Makita N. Inherited bradyarrhythmia: A diverse genetic background. Arrhythmia In press (2016). doi:10.1016/j.joa.2015.09.009 (Science Direct) (pdf)
  4. Koizumi A, Sasano T, Kimura W, Miyamoto Y, Aiba Koizumi A, Sasano T, Kimura W, Miyamoto Y, Aiba T, Ishikawa T, Nogami A, Fukamizu S, Sakurada H, Takahashi Y, Nakamura H, Ishikura T, Koseki H, Arimura T, Kimura A, Hirao K, Isobe M, Shimizu W, Miura N,Furukawa T. Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. Eur Heart J 37, 1469-1475(2016). doi:10.1093/eurheartj/ehv449  (PubMed:26429810) (pdf)
  5. Daumy X, Amarouch MY, Lindenbaum P, Bonnaud S,Bianchi B, Nafzger S, Baron E, Fouchard S, Thollet A, Kyndt F, Barc J, Le Scouarnec S, Makita N, Le Marec H, Dina C, Gourraud J, Probst V, Abriel H, Redon R, Schott J. Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I. Int J Cardiol. 207:349-358(2016).doi:10.1016/j.ijcard.2016.01.052(pdf)

<2015>

  1. Yamamoto T, Shimano M, Inden Y, Takefuji M, Yanagisawa S, Yoshida N, Tsuji Y, Hirai M,Murohara T. Alogliptin, a dipeptidyl peptidase-4 inhibitor, regulates the atrial arrhythmogenic substrate in rabbits. Heart Rhythm 12, 1362-1369(2015). doi:10.1016/j.hrthm.2015.03.010 (pdf)
  2. Nademanee K, Raju H, de Noronha, S, Papadakis M, Robinson L, Rothery S, Makita N, Kowase S, Boonmee, N, Vitayakritsirikul, V, Ratanarapee, S, Sharma, S, van der Wal, A, Christiansen, M, Tan, Hanno, Wilde. A, Nogami, A, Sheppard, M, Gumpanart V, Behr, E. Fibrosis, Connexin43 and Conduction Abnormalities in the Brugada Syndrome. J Am Coll Cardiol. 2015; 66(18):1976-1986. (2015). doi:10.1016/j.jacc.2015.08.862 (PubMed: 26516000) (pdf)
  3. Maharani N, Ting Y, Cheng J, Hasegawa A, Kurata Y, Li P, Nakayama Y, Haruaki N, Nobuhito I, Morikawa K, Yamamoto K, Makita N, Yamashita T, Shirayoshi Y, Hisatome I. Molecular mechanisms underlying urate-induced enhancement of Kv1.5 channel expression in HL-1 atrial myocytes. Circ J. 2015 Nov 25;79(12):2659-68 (2015). doi:10.1253/circj.CJ-15-0416 (PubMed: 26477273) (pdf)
  4. Ishikawa T, Jou CJ, Nogami A, Kowase S, Arrington CB, Spencer M. Barnett SM, Harrell DT, Arimura T, Tsuji Y, Kimura A, Makita N. A novel mutation in the α-myosin heavy chain gene is associated with sick sinus syndrome. Circ Arrhythm Electrophysiol.2015; 8: 400-408. (2015). doi:10.1161/CIRCEP.114.002534 (PubMed: 25717017) (pdf)
  5. Hayashi K, Konno T, Tada H, Tani S, Liu L, Fujino N, Nohara A, Hodatsu A, Tsuda T, Tanaka Y, Kawashiri M, Ino H, Makita N, Yamagishi M. Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.  Circ Arrhythm Electrophysiol.2015; 8: 1095-1104 (2015). doi:10.1161/CIRCEP.114.002519 (PubMed: 26129877) (pdf)
  6. Harrell DT, Ashihara T, Ishikawa T, Tominaga I, Mazzanti A, Takahashi K, Oginosawa Y, Abe H, Maemura K, Sumitomo N, Uno K, Takano M, Priori SG, Makita N. Genotype-dependent difference in age of manifestation and arrhythmia complication in short QT syndrome. Int J Cardiol. 2015;190:393-402.(2015). doi:10.1016/j.ijcard.2015.04.090 (PubMed: 25974115) (pdf)

<2014>

  1. Yoshida M, Ando S, Chishaki A, Makita N, Hasegawa Y, Narita S, Momii H, Kadokami T. Normal dose of pilsicainide showed marked negative inotropic effects in a patient who had no underlying heart disease. J Arrhythmia. 2014;30:68-70. (Science Direct)  (pdf)
  2. Tsuji Y, Ishikawa T, Makita N. Molecular mechanisms of heart failure progression associated with implantable cardioverter-defibrillator shocks for ventricular tachyarrhythmias. J Arrhythmia. 2014;30:235-241. (Science Direct) (pdf)
  3. Ohno S, Omura M, Kawamura M, Kimura H, Itoh H, Makiyama T, Ushinohama H, Makita N, Horie M. Exon 3 deletion of RYR2 encoding cardiac ryanodine receptor is associated with left ventricular non-compaction. Europace. 2014;16:1646-1654. (PubMed: 24394973)
  4. Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kaab S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL, Jr. Novel calmodulin mutations associated with congenital arrhythmia susceptibility. Circ Cardiovasc Genet. 2014;7:466-474. (PubMed: 24917665)
  5. Kusumoto S, Kawano H, Makita N, Ichimaru S, Kaku T, Haruta D, Hida A, Sera N, Imaizumi M, Nakashima E, Maemura K, Akahoshi M. Right bundle branch block without overt heart disease predicts higher risk of pacemaker implantation: The study of atomic-bomb survivors. Int J Cardiol. 2014;174:77-82. (PubMed: 24745858)
  6. Katsuumi G, Shimizu W, Watanabe H, Noda T, Nogami A, Ohkubo K, Makiyama T, Takehara N, Kawamura Y, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Makita N, Minamino T. Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome. Int J Cardiol. 2014;172:519-522. (PubMed: 24491875)
  7. Hasegawa K, Ohno S, Itoh H, Makiyama T, Aiba T, Nakano Y, Shimizu W, Matsuura H, Makita N, Horie M. A rare KCNE1 polymorphism, D85N, as a genetic modifier of long QT syndrome. J Arrhythmia. 2014;30:161-166. (Science Direct) (pdf)
  8. Abe Y, Sumitomo N, Okuma H, Nakamura T, Fukuhara J, Ichikawa R, Matsumura M, Miyashita M, Kamiyama H, Ayusawa M, Watanabe M, Joo K, Makita N, Horie M. Successful control of life-threatening polymorphic ventricular tachycardia by radiofrequency catheter ablation in an infant. Heart Vessels. 2014;29:422-426. (PubMed: 23836069)
  9. Abe K, Machida T, Sumitomo N, Yamamoto H, Ohkubo K, Watanabe I, Makiyama T, Fukae S, Kohno M, Harrell DT, Ishikawa T, Tsuji Y, Nogami A, Watabe T, Oginosawa Y, Abe H, Maemura K, Motomura H, Makita N. Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics. Circ Arrhythm Electrophysiol. 2014;7:511-517. (PubMed: 24762805)

 <2013>

  1. Watanabe H, Ohkubo K, Watanabe I, Matsuyama TA, Ishibashi-Ueda H, Yagihara N, Shimizu W, Horie M, Minamino T, Makita N. SCN5A mutation associated with ventricular fibrillation, early repolarization, and concealed myocardial abnormalities. Int J Cardiol. 2013;165:e21-23. (PubMed: 23168001)
  2. Nakano Y, Chayama K, Ochi H, Toshishige M, Hayashida Y, Miki D, Hayes CN, Suzuki H, Tokuyama T, Oda N, Suenari K, Uchimura-Makita Y, Kajihara K, Sairaku A, Motoda C, Fujiwara M, Watanabe Y, Yoshida Y, Ohkubo K, Watanabe I, Nogami A, Hasegawa K, Watanabe H, Endo N, Aiba T, Shimizu W, Ohno S, Horie M, Arihiro K, Tashiro S, Makita N, Kihara Y. A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation. PLoS Genet. 2013;9:e1003364. (PubMed: 23593010)
  3. Makita N. Paradigm shifts in the genetics of inherited arrhythmias: Using next-generation sequencing technologies to uncover hidden etiologies. J Arrhythmia. 2013;29:305-307. (Science Direct) (pdf)
  4. Kawakami H, Aiba T, Yamada T, Okayama H, Kazatani Y, Konishi K, Nakajima I, Miyamoto K, Yamada Y, Okamura H, Noda T, Satomi K, Kamakura S, Makita N, Shimizu W. Variable phenotype expression with a frameshift mutation of the cardiac sodium channel gene SCN5A. J Arrhythmia. 2013;29:291-295. (Science Direct) (pdf)
  5. Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A. Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5. Circ J. 2013;77:959-967. (PubMed: 23257389)
  6. Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud J-B, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kaab S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bezieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Marec HL, Wilde AA, Probst V, Schott JJ, Dina C, Redon R. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet. 2013;45:1044-1049. (PubMed: 23872634)
  7. Arimura T, Takeya R, Ishikawa T, Yamano T, Matsuo A, Tatsumi T, Nomura T, Sumimoto H, Kimura A. Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor. Circ J. 2013;77:2990-2996. (PubMed: 24088304)
  8. Arimura T, Onoue K, Takahashi-Tanaka Y, Ishikawa T, Kuwahara M, Setou M, Shigenobu S, Yamaguchi K, Bertrand AT, Machida N, Takayama K, Fukusato M, Tanaka R, Somekawa S, Nakano T, Yamane Y, Kuba K, Imai Y, Saito Y, Bonne G, Kimura A. Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations. Cardiovasc Res. 2013;99:382-394. (PubMed: 23631840)

 <2012>

  1. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N. Response to Letter Regarding Article, “Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization”. Circ Arrhythm Electrophysiol. 2012;5:e60-e61. (Link) (pdf)
  2. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N. Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization. Int J Cardiol. 2012;159:238-240. (PubMed: 22709726)
  3. Watanabe H, Makita N, Tanabe N, Watanabe T, Aizawa Y. Electrocardiographic abnormalities and risk of complete atrioventricular block. Int J Cardiol. 2012;155:462-464. (PubMed: 22225759)
  4. Shimada T, Ohkubo K, Abe K, Watanabe I, Makita N. A novel 5′ splice site mutation of SCN5A associated with Brugada syndrome resulting in multiple cryptic transcripts. Int J Cardiol. 2012;158:441-443. (PubMed: 22633666)
  5. Makita N, Seki A, Sumitomo N, Chkourko H, Fukuhara S, Watanabe H, Shimizu W, Bezzina CR, Hasdemir C, Mugishima H, Makiyama T, Baruteau A, Baron E, Horie M, Hagiwara N, Wilde AA, Probst V, Le Marec H, Roden DM, Mochizuki N, Schott JJ, Delmar M. A connexin40 mutation associated with a malignant variant of progressive familial heart block type I. Circ Arrhythm Electrophysiol. 2012;5:163-172. (PubMed: 22247482)
  6. Ishikawa T, Sato A, Marcou CA, Tester DJ, Ackerman MJ, Crotti L, Schwartz PJ, On YK, Park JE, Nakamura K, Hiraoka M, Nakazawa K, Sakurada H, Arimura T, Makita N, Kimura A. A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.5. Circ Arrhythm Electrophysiol. 2012;5:1098-1107. (PubMed: 23064965)
  7. Egashira T, Yuasa S, Suzuki T, Aizawa Y, Yamakawa H, Matsuhashi T, Ohno Y, Tohyama S, Okata S, Seki T, Kuroda Y, Yae K, Hashimoto H, Tanaka T, Hattori F, Sato T, Miyoshi S, Takatsuki S, Murata M, Kurokawa J, Furukawa T, Makita N, Aiba T, Shimizu W, Horie M, Kamiya K, Kodama I, Ogawa S, Fukuda K. Disease characterization using LQTS-specific induced pluripotent stem cells. Cardiovasc Res. 2012;95:419-429. (PubMed: 22739119)
  8. Delmar M, Makita N. Cardiac connexins, mutations and arrhythmias. Curr Opin Cardiol. 2012;27:236-241. (PubMed: 22382502)

 <2011>

  1. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N. Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization. Circ Arrhythm Electrophysiol. 2011;4:874-881. (PubMed: 22028457)
  2. Makita N. Phenotypic overlap of lethal arrhythmias associated with cardiac sodium mutations. Individual-specific or mutation-specific? . Genes and Cardiovascular Function. 2011:185-196. (Springer Link) (pdf)

 <2010>

 <2009>

  1. Sato A, Arimura T, Makita N, Ishikawa T, Aizawa Y, Ushinohama H, Aizawa Y, Kimura A. Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome. J Biol Chem. 284(50), 35122-33(2009). doi:10.1074/jbc.M109.017293. (pdf)
  2. Tsurugi T, Nagatomo T, Abe H, Oginosawa Y, Takemasa H, Kohno R, Makita N, Makielski JC, Otsuji Y. Differential modulation of late sodium current by protein kinase A in R1623Q mutant of LQT3. Life Sci. 2009;84:380-387. (PubMed: 19167409)
  3. Okishige K, Sugiyama K, Maeda M, Aoyagi H, Kurabayashi M, Miyagi N, Ueshima D, Azegami K, Takei T, Itoh T, Makita N. Aborted sudden death associated with short QT syndrome. Arrhythmia. 2009;25:214-218. (Science Direct) (pdf)
  4. Makita N. Phenotypic overlap of cardiac sodium channelopathies: individual-specific or mutation-specific? Circ J. 2009;73:810-817. (PubMed: 19336922)
  5. Kamakura S, Ohe T, Nakazawa K, Aizawa Y, Shimizu A, Horie M, Ogawa S, Okumura K, Tsuchihashi K, Sugi K, Makita N, Hagiwara N, Inoue H, Atarashi H, Aihara N, Shimizu W, Kurita T, Suyama K, Noda T, Satomi K, Okamura H, Tomoike H. Long-term prognosis of probands with Brugada-pattern ST-elevation in leads V1-V3. Circ Arrhythm Electrophysiol. 2009;2:495-503. (PubMed: 19843917)

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