Nagasaki U Link
Nagasaki University Graduate School of Biomedical Sciences 長崎大学学院医歯薬学総合研究科
 

分子生理学研究室 業績集

<2018>

英文論文

  1. Tsuji Y, Dobrev D. Prognostic impact of electrical storm in patients with implantable cardioverter defibrillators: Mechanistic and therapeutic considerations to reduce the risk of death. International Journal of Cardiology 255: 101-102(2018).(pdf)
  2. Kozasa Y, Nakashima N, Ito M, Ishikawa T, Kimoto H, Ushijima K, Makita N, Takano M. HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node. Journal of Physiology 596(5): 809-825(2018).(pdf)
  3. Nakajima K, Aiba T, Makiyama T, Nishiuchi S, Ohno S, Kato K, Yamamoto Y, Doi T, Shizuta S, Onoue K, Yagihara N, Ishikawa T, Watanabe I, Kawakami H, Oginosawa Y, Murakoshi N, Nogami A, Aonuma K, Saito Y, Kimura T, Yasuda S, Makita N, Shimizu W, Horie M, Kusano K. Clinical Manifestations and Long-term Mortality in Lamin A/C Mutation Carriers from the Japanese Multicenter Registry. Circulation Journal 2018 (in press).
  4. Gray B, Hasdemir C Ingles, J, Aiba T, Makita N, Probst V, Wilde A A M, Newbury-Ecob R,
    Sheppard M N, Semsarian C, Sy R W, Behr E R. Lack of genotype-phenotype correlation in Brugada Syndrome and Sudden Arrhythmic Death Syndrome families with reported pathogenic SCN1B variants. Heart Rhythm 15(7): 1051-1057 (2018). (pdf)
  5. Arimura T, Muchir A, Kuwahara M, Morimoto S, Ishikawa T, Du C K, Zhan D Y, Nakao S, Machida N, Tanaka R, Yamane Y, Hayashi T, Kimura A. Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance. American Journal of Physiology: Heart and Circulatory Physiology 314(6): H1192-H1202 (2018). (pdf)
  6. Nakano Y, Ochi H, Sairaku A, Onohara Y, Tokuyama T, Motoda C, Matsumura H, Tomomori S, Amioka M, Hironobe N, Ohkubo Y, Okamura S, Makita N, Yoshida Y, Chayama K, Kihara Y. HCN4 Gene Polymorphisms Are Associated With Occurrence of Tachycardia-Induced Cardiomyopathy in Patients With Atrial Fibrillation. Circ Genom Precis Med 11(7): e001980 (2018). (pdf)

 

<2017>

英文論文

  1. Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Hirose S, Kohjitani H, Yamamoto Y, Harita T, Hayano M, Wuriyanghai Y, Chen J, Sasaki K, Yagihara N, Ishikawa T, Onoue K, Murakoshi N, Watanabe I, Ohkubo K, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K, Makita N, Shimizu W, Horie M, Kimura T. Gene-based risk stratification for cardiac disorders in LMNA mutation carriers. Circ Cardiovasc Genet. 2017 (in press). (pdf)
  2. Oshima Y, Yamamoto T, Ishikawa T, Mishima H, Matsusue A, Umehara T, Murase T, Abe Y, Kubo SI, Yoshiura KI, Makita N, Ikematsu K. Postmortem genetic analysis of sudden unexpected death in infancy: neonatal genetic screening may enable the prevention of sudden infant death. J. Hum. Genet. 62(11), 989-995(2017). doi:10.1038/jhg.2017.79. (pdf)
  3. Seki A, Ishikawa T, Daumy X, Mishima H, Barc J, Sasaki R, Nishii K, Saito K, Urano M, Ohno S, Otsuki S, Kimoto H, Baruteau A, Thollet A, Fouchard S, Bonnaud S, Parent P, Shibata Y, Perrin J.P, Le Marec H, Hagiwara N, Mercier S, Horie M, Probst V, Yoshiura K.I, Redon R, Schott J.J, Makita N. Progressive atrial conduction system defects associated with bone malformation caused by a connexin45 mutation. J Am Coll Cardiol 70(3), 358-70 (2017). doi:10.1016/j.jacc.2017.05.039. (pdf)
  4. Ishikawa T, Makita N, Aoki H, Saida Y. Letter to the Editor J Vet Intern Med. 31(4):967-968.(2017). doi:10.1111/jvim.14781. (pdf)
  5. Yamamoto Y, Makiyama T, Harita T, Sasaki K, Wuriyanghai Y, Hayano M, Nishiuchi S, Kohjitani H, Hirose S, Chen J, Yokoi F, Ishikawa T, Ohno S, Chonabayashi K, Motomura H, Yoshida Y, Horie M, Makita N, Kimura T. Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation. Hum Mol Genet 29(9), 1670-1677 (2017). doi:10.1093/hmg/ddx073. (pdf)
  6. Yamagata K, Horie M, Aiba T, Ogawa S, Aizawa Y, Ohe T, Yamagishi M, Makita N, Sakurada H, Tanaka T, Shimizu A, Hagiwara N, Kishi R, Nakano Y, Takagi M, Makiyama T, Ohno S, Fukuda K, Watanabe H, Morita H, Hayashi K, Fukushima-Kusano K, Kamakura S, Yasuda S, Ogawa H, Y. M, Kapplinger J, Ackerman M, Shimizu W. Genotype-phenotype correlation of SCN5A mutation for clinical and electrocardiographic characteristics of probands with Brugada syndrome: A Japanese multicenter registry. Circulation 135(23), 2255-2270 (2017). doi:10.1161/CIRCULATIONAHA.117.027983. (pdf)
  7. Takahashi K, Ishikawa T, Makita N, Takefuta K, Nabeshima T, Nakayashiro M. A novel de novo calmodulin mutation in a 6-year-old boy who experienced an aborted cardiac arrest. HeartRhythm Case Reports 3, 69-72 (2017). doi:10.1016/j.hrcr.2016.09.004(2017) (pdf)
  8. Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Hattori T, Ohno S, Kodaira M, Suzuki T, Hashimoto H, Okata S, Tanaka A, Aizawa Y, Murata M, Aiba T, Makita N, Furukawa T, Shimizu W, Kodama I, Ogawa S, Kokubun N, Horigome H, Horie M, Kamiya K, Fukuda K. Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochemistry and Biophysics Reports 9, 245-256 (2017). doi:10.1016/j.bbrep.2017.01.002 (pdf)
  9. Ishikawa T, Ohno S, Murakami T, Yoshida K, Mishima H, Fukuoka T, Kimoto H, Sakamoto R, Ohkusa T, Aiba T, Nogami A, Sumitomo N, Shimizu W, Yoshiura KI, Horigome H, Horie M, Makita N. Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction. Heart Rhythm 14(5), 717-724 (2017). doi:10.1016/j.hrthm.2017.01.020 (pdf)
  10. Hu D, Li Y, Zhang J, Pfeiffer R, Gollob MH, Healey J, Harrell DT, Makita N, Abe H, Sun Y, Guo J, Zhang L, Yan G, Mah D, Walsh EP, Leopold HB, Giustetto C, Gaita F, Zienciuk-Krajka A, Mazzanti A, Priori SG, Antzelevitch C, Barajas-Martinez H. The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome. JACC: Clinical Electrophysiology 320 (2017). doi:10.1016/j.jacep.2016.11.013 (pdf)

和文論文

  1. 蒔田直昌.Brugada症候群の遺伝的背景と遺伝子診断.医学のあゆみ. 262(9),763-766.(2017).(pdf)

 

<2016>

英文論文

  1. Okata S, Yuasa S, Suzuki T, Ito S, Makita N, Yoshida T, Lin M, Kurokawa J, Seki T, Egashira T, Aizawa Y, Kodaira M, Motoda C, Yozu G, Shimojima M, Hayashiji N, Hashimoto H, Kuroda Y, Tanaka A, Murata M, Aiba T, Shimizu W, Horie M, Kamiya K, Furukawa T,Fukuda K. Embryonic type Na+ channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome. Scientific Reports 6, 34198 (2016). doi:10.1038/srep34198, (pdf)
  2. Yagihara N, Watanabe H, Barnett P, Duboscq-Bidot L, Thomas AC, Yang P, Ohno S, Hasegawa K, Kuwano R, Chatel S, Redon R, Schott J, Probst V, Koopmann TT, Bezzina CR, Wilde AAM, Nakano Y, Aiba T, Miyamoto Y, Kamakura S, Darbar D, Donahue B, Shigemizu D, Tanaka T, Tsunoda T, Suda M, Sato A, Minamino T, Endo N, Shimizu W, Horie M, Roden D,Makita N. Variants in the SCN5A promoter associated with various arrhythmia phenotypes. J Am Heart Assoc 5,e003644,2016(2016) (pdf)
  3. Ishikawa T, Tsuji Y,Makita N. Inherited bradyarrhythmia: A diverse genetic background. Arrhythmia 32, 352-358(2016). doi:10.1016/j.joa.2015.09.009 (pdf)
  4. Koizumi A, Sasano T, Kimura W, Miyamoto Y, Aiba Koizumi A, Sasano T, Kimura W, Miyamoto Y, Aiba T, Ishikawa T, Nogami A, Fukamizu S, Sakurada H, Takahashi Y, Nakamura H, Ishikura T, Koseki H, Arimura T, Kimura A, Hirao K, Isobe M, Shimizu W, Miura N,Furukawa T. Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. Eur Heart J 37, 1469-1475(2016).doi:10.1093/eurheartj/ehv449 (pdf)
  5. Daumy X, Amarouch MY, Lindenbaum P, Bonnaud S,Bianchi B, Nafzger S, Baron E, Fouchard S, Thollet A, Kyndt F, Barc J, Le Scouarnec S, Makita N, Le Marec H, Dina C, Gourraud J, Probst V, Abriel H, Redon R, Schott J. Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I. Int J Cardiol. 207:349-358(2016).doi:10.1016/j.ijcard.2016.01.052(pdf)

 

和文論文

  1.  辻幸臣.CaMKⅡと不整脈.心電図. 36,296-301.(2016).

 

<2015>

英文論文

  1. Yamamoto T, Shimano M, Inden Y, Takefuji M, Yanagisawa S, Yoshida N, Tsuji Y, Hirai M,Murohara T. Alogliptin, a dipeptidyl peptidase-4 inhibitor, regulates the atrial arrhythmogenic substrate in rabbits. Heart Rhythm 12, 1362-1369(2015). doi:10.1016/j.hrthm.2015.03.010 (pdf)
  2. Nademanee K, Raju H, de Noronha, S, Papadakis M, Robinson L, Rothery S, Makita N, Kowase S, Boonmee, N, Vitayakritsirikul, V, Ratanarapee, S, Sharma, S, van der Wal, A, Christiansen, M, Tan, Hanno, Wilde. A, Nogami, A, Sheppard, M, Gumpanart V, Behr, E. Fibrosis, Connexin43 and Conduction Abnormalities in the Brugada Syndrome. J Am Coll Cardiol. 2015; 66(18):1976-1986. (2015). doi:10.1016/j.jacc.2015.08.862 (pdf)
  3. Maharani N, Ting Y, Cheng J, Hasegawa A, Kurata Y, Li P, Nakayama Y, Haruaki N, Nobuhito I, Morikawa K, Yamamoto K, Makita N, Yamashita T, Shirayoshi Y, Hisatome I. Molecular mechanisms underlying urate-induced enhancement of Kv1.5 channel expression in HL-1 atrial myocytes. Circ J. 2015 Nov 25;79(12):2659-68 (2015). doi:10.1253/circj.CJ-15-0416 (pdf)
  4. Ishikawa T, Jou CJ, Nogami A, Kowase S, Arrington CB, Spencer M. Barnett SM, Harrell DT, Arimura T, Tsuji Y, Kimura A, Makita N. A novel mutation in the α-myosin heavy chain gene is associated with sick sinus syndrome. Circ Arrhythm Electrophysiol.2015; 8: 400-408. (2015). doi:10.1161/CIRCEP.114.002534 (pdf)
  5. Hayashi K, Konno T, Tada H, Tani S, Liu L, Fujino N, Nohara A, Hodatsu A, Tsuda T, Tanaka Y, Kawashiri M, Ino H, Makita N, Yamagishi M. Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.  Circ Arrhythm Electrophysiol.2015; 8: 1095-1104 (2015). doi:10.1161/CIRCEP.114.002519 (pdf)
  6. Harrell DT, Ashihara T, Ishikawa T, Tominaga I, Mazzanti A, Takahashi K, Oginosawa Y, Abe H, Maemura K, Sumitomo N, Uno K, Takano M, Priori SG, Makita N. Genotype-dependent difference in age of manifestation and arrhythmia complication in short QT syndrome. Int J Cardiol. 2015;190:393-402.(2015). doi:10.1016/j.ijcard.2015.04.090 (pdf)

 

和文論文

  1. 辻幸臣, Daniel Toshio Harrell, 石川泰輔,蒔田直昌.心電図. 2015; 35: 104-115.
  2. 石川泰輔, 蒔田直昌. 徐脈性疾患と分子遺伝学. 循環器内科. 2015;77:360-365.
  3. 蒔田直昌. 早期再分極(J波)症候群の遺伝子解析~危険なJ波は見極められるか? 不整脈症候群-遺伝子変異から不整脈治療を捉えるー. 2015:116-120. (pdf)
  4. 石川泰輔, 蒔田直昌. Brugada症候群の遺伝子診断~有効性と限界 不整脈症候群-遺伝子変異から不整脈治療を捉えるー. 2015:82-85. (pdf)

 

<2014>

英文論文

  1. Yoshida M, Ando S, Chishaki A, Makita N, Hasegawa Y, Narita S, Momii H, Kadokami T. Normal dose of pilsicainide showed marked negative inotropic effects in a patient who had no underlying heart disease. J Arrhythmia. 2014;30:68-70. (Science Direct)  (pdf)
  2. Tsuji Y, Ishikawa T, Makita N. Molecular mechanisms of heart failure progression associated with implantable cardioverter-defibrillator shocks for ventricular tachyarrhythmias. J Arrhythmia. 2014;30:235-241. (Science Direct) (pdf)
  3. Ohno S, Omura M, Kawamura M, Kimura H, Itoh H, Makiyama T, Ushinohama H, Makita N, Horie M. Exon 3 deletion of RYR2 encoding cardiac ryanodine receptor is associated with left ventricular non-compaction. Europace. 2014;16:1646-1654. (PubMed: 24394973)
  4. Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kaab S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL, Jr. Novel calmodulin mutations associated with congenital arrhythmia susceptibility. Circ Cardiovasc Genet. 2014;7:466-474. (PubMed: 24917665)
  5. Kusumoto S, Kawano H, Makita N, Ichimaru S, Kaku T, Haruta D, Hida A, Sera N, Imaizumi M, Nakashima E, Maemura K, Akahoshi M. Right bundle branch block without overt heart disease predicts higher risk of pacemaker implantation: The study of atomic-bomb survivors. Int J Cardiol. 2014;174:77-82. (PubMed: 24745858)
  6. Katsuumi G, Shimizu W, Watanabe H, Noda T, Nogami A, Ohkubo K, Makiyama T, Takehara N, Kawamura Y, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Makita N, Minamino T. Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome. Int J Cardiol. 2014;172:519-522. (PubMed: 24491875)
  7. Hasegawa K, Ohno S, Itoh H, Makiyama T, Aiba T, Nakano Y, Shimizu W, Matsuura H, Makita N, Horie M. A rare KCNE1 polymorphism, D85N, as a genetic modifier of long QT syndrome. J Arrhythmia. 2014;30:161-166. (Science Direct) (pdf)
  8. Abe Y, Sumitomo N, Okuma H, Nakamura T, Fukuhara J, Ichikawa R, Matsumura M, Miyashita M, Kamiyama H, Ayusawa M, Watanabe M, Joo K, Makita N, Horie M. Successful control of life-threatening polymorphic ventricular tachycardia by radiofrequency catheter ablation in an infant. Heart Vessels. 2014;29:422-426. (PubMed: 23836069)
  9. Abe K, Machida T, Sumitomo N, Yamamoto H, Ohkubo K, Watanabe I, Makiyama T, Fukae S, Kohno M, Harrell DT, Ishikawa T, Tsuji Y, Nogami A, Watabe T, Oginosawa Y, Abe H, Maemura K, Motomura H, Makita N. Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics. Circ Arrhythm Electrophysiol. 2014;7:511-517. (PubMed: 24762805)

 

和文論文

  1. 辻幸臣, 蒔田直昌. 重症不整脈 electrical storm : 基礎研究からのアプローチ. 長崎市医師会報 2014;48:7-11. (pdf)
  2. 清水渉, 蒔田直昌, 堀江稔, 相庭武司. わが国における遺伝性不整脈診断・治療の今後の展望-欧米との違いも含めて. CARDIAC PRACTICE. 2014;25:65-72. (pdf)
  3. 蒔田直昌. 遺伝性不整脈の遺伝子診断の歴史. 呼吸と循環. 2014;62:827-831. (pdf)

<2013>

英文論文

  1. Watanabe H, Ohkubo K, Watanabe I, Matsuyama TA, Ishibashi-Ueda H, Yagihara N, Shimizu W, Horie M, Minamino T, Makita N. SCN5A mutation associated with ventricular fibrillation, early repolarization, and concealed myocardial abnormalities. Int J Cardiol. 2013;165:e21-23. (PubMed: 23168001)
  2. Nakano Y, Chayama K, Ochi H, Toshishige M, Hayashida Y, Miki D, Hayes CN, Suzuki H, Tokuyama T, Oda N, Suenari K, Uchimura-Makita Y, Kajihara K, Sairaku A, Motoda C, Fujiwara M, Watanabe Y, Yoshida Y, Ohkubo K, Watanabe I, Nogami A, Hasegawa K, Watanabe H, Endo N, Aiba T, Shimizu W, Ohno S, Horie M, Arihiro K, Tashiro S, Makita N, Kihara Y. A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation. PLoS Genet. 2013;9:e1003364. (PubMed: 23593010)
  3. Makita N. Paradigm shifts in the genetics of inherited arrhythmias: Using next-generation sequencing technologies to uncover hidden etiologies. J Arrhythmia. 2013;29:305-307. (Science Direct) (pdf)
  4. Kawakami H, Aiba T, Yamada T, Okayama H, Kazatani Y, Konishi K, Nakajima I, Miyamoto K, Yamada Y, Okamura H, Noda T, Satomi K, Kamakura S, Makita N, Shimizu W. Variable phenotype expression with a frameshift mutation of the cardiac sodium channel gene SCN5A. J Arrhythmia. 2013;29:291-295. (Science Direct) (pdf)
  5. Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A. Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5. Circ J. 2013;77:959-967. (PubMed: 23257389)
  6. Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud J-B, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kaab S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bezieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Marec HL, Wilde AA, Probst V, Schott JJ, Dina C, Redon R. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet. 2013;45:1044-1049. (PubMed: 23872634)
  7. Arimura T, Takeya R, Ishikawa T, Yamano T, Matsuo A, Tatsumi T, Nomura T, Sumimoto H, Kimura A. Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor. Circ J. 2013;77:2990-2996. (PubMed: 24088304)
  8. Arimura T, Onoue K, Takahashi-Tanaka Y, Ishikawa T, Kuwahara M, Setou M, Shigenobu S, Yamaguchi K, Bertrand AT, Machida N, Takayama K, Fukusato M, Tanaka R, Somekawa S, Nakano T, Yamane Y, Kuba K, Imai Y, Saito Y, Bonne G, Kimura A. Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations. Cardiovasc Res. 2013;99:382-394. (PubMed: 23631840)

 

和文論文

  1. 蒔田直昌. 難治性不整脈の遺伝子解析. 循環器専門医. 2013;21:3-8. (pdf)
  2. 蒔田直昌. 進行性心臓伝導障害. 医学のあゆみ. 2013;245:802-809. (pdf)
  3. 蒔田直昌. 致死性不整脈診療 遺伝性心臓伝導障害. 最新医学. 2013;68:1588-1596. (pdf)
  4. 蒔田直昌. 心臓伝導障害の遺伝子基盤. 不整脈2013. 2013:12-22. (pdf)
  5. 蒔田直昌. 遺伝性不整脈研究の黎明期とその後の急速な展開. 日本心電学会30年の軌跡. 2013:154-157.
  6. 蒔田直昌. Editorial: 不整脈の病因研究におけるパラダイムシフト. 心電図. 2013;33:1-2. (pdf)
  7. 蒔田直昌. 進行性心臓伝導障害の基礎と臨床. 心電図. 2013;33:S3-34-42. (pdf)

<2012>

英文論文

  1. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N. Response to Letter Regarding Article, “Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization”. Circ Arrhythm Electrophysiol. 2012;5:e60-e61. (Link) (pdf)
  2. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N. Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization. Int J Cardiol. 2012;159:238-240. (PubMed: 22709726)
  3. Watanabe H, Makita N, Tanabe N, Watanabe T, Aizawa Y. Electrocardiographic abnormalities and risk of complete atrioventricular block. Int J Cardiol. 2012;155:462-464. (PubMed: 22225759)
  4. Shimada T, Ohkubo K, Abe K, Watanabe I, Makita N. A novel 5′ splice site mutation of SCN5A associated with Brugada syndrome resulting in multiple cryptic transcripts. Int J Cardiol. 2012;158:441-443. (PubMed: 22633666)
  5. Makita N, Seki A, Sumitomo N, Chkourko H, Fukuhara S, Watanabe H, Shimizu W, Bezzina CR, Hasdemir C, Mugishima H, Makiyama T, Baruteau A, Baron E, Horie M, Hagiwara N, Wilde AA, Probst V, Le Marec H, Roden DM, Mochizuki N, Schott JJ, Delmar M. A connexin40 mutation associated with a malignant variant of progressive familial heart block type I. Circ Arrhythm Electrophysiol. 2012;5:163-172. (PubMed: 22247482)
  6. Ishikawa T, Sato A, Marcou CA, Tester DJ, Ackerman MJ, Crotti L, Schwartz PJ, On YK, Park JE, Nakamura K, Hiraoka M, Nakazawa K, Sakurada H, Arimura T, Makita N, Kimura A. A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.5. Circ Arrhythm Electrophysiol. 2012;5:1098-1107. (PubMed: 23064965)
  7. Egashira T, Yuasa S, Suzuki T, Aizawa Y, Yamakawa H, Matsuhashi T, Ohno Y, Tohyama S, Okata S, Seki T, Kuroda Y, Yae K, Hashimoto H, Tanaka T, Hattori F, Sato T, Miyoshi S, Takatsuki S, Murata M, Kurokawa J, Furukawa T, Makita N, Aiba T, Shimizu W, Horie M, Kamiya K, Kodama I, Ogawa S, Fukuda K. Disease characterization using LQTS-specific induced pluripotent stem cells. Cardiovasc Res. 2012;95:419-429. (PubMed: 22739119)
  8. Delmar M, Makita N. Cardiac connexins, mutations and arrhythmias. Curr Opin Cardiol. 2012;27:236-241. (PubMed: 22382502)

 

和文論文

  1. 蒔田直昌. 器質的心疾患を伴わない致死性不整脈の診断と治療. 日本集中治療医学会雑誌. 2012;19:163.
  2. 蒔田直昌. イオンチャネル研究の最先端 家族性進行性心臓伝導障害(PCCD)の臨床像と分子病態. 血管. 2012;35:25.
  3. 蒔田直昌. 特発性心室細動とJ波症候群の遺伝子診断. CIRCULATION Up-to-Date. 2012;7:20-25. (pdf)
  4. 蒔田直昌. ブルガタ症候群. 内科. 2012;109:1020-1022. (pdf)
  5. 蒔田直昌. 遺伝子とチャネルからみた先天性QT延長症候群. 不整脈学. 2012:491-495.  (pdf)
  6. 蒔田直昌. 早期再分極とJ波症候群:オーバービュー. 心臓. 2012;44:1226-1231. (pdf)

 

 <2011>

英文論文

  1. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N. Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization. Circ Arrhythm Electrophysiol. 2011;4:874-881. (PubMed: 22028457)
  2. Makita N. Phenotypic overlap of lethal arrhythmias associated with cardiac sodium mutations. Individual-specific or mutation-specific? . Genes and Cardiovascular Function. 2011:185-196. (Springer Link) (pdf)

 

和文論文

  1. 蒔田直昌. Brugada症候群・J波症候群の遺伝子異常. 心電図. 2012;32:47-55.
  2. 嶋田敏生, 松本逸郎, 蒔田直昌. 血小板活性化因子(PAF)による副腎皮質ホルモン分泌に対するPAF誘導体とスフィンゴシン誘導体の調節作用. 日本生理学雑誌. 2011;73:17-18.
  3. 松本逸郎, 嶋田敏生, 蒔田直昌. 酸性線維芽細胞増殖因子はセロトニンとNOを介して発熱させる. 日本生理学雑誌. 2011;73:17.
  4. 蒔田直昌. 遺伝性心臓伝導障害の分子基盤. 循環器内科. 2011;70:460-467. (pdf)
  5. 蒔田直昌. 致死性不整脈の基礎と臨床 特発性心室細動. 臨牀と研究. 2011;88:775-777.
  6. 蒔田直昌. 後天性QT延長症候群の新しい展開. 不整脈+PLUS. 2011:3-8.

 <2010>

英文論文

 

和文論文

  1. 牧元久樹, 堀江稔, 小川聡, 相澤義房, 大江透, 草野研吾, 山岸正和, 蒔田直昌, 田中敏博, 牧山武, 吉永正夫, 萩原誠久, 鎌倉史郎, 宮本恵宏, 清水渉. 心血管疾患の遺伝子解析とその意義 先天性QT延長症候群の遺伝子解析とその臨床的有用性 日本国内多施設登録からの検討. 日本心臓病学会誌. 2010;5:142.
  2. 蒔田直昌, 住友直方, 関明子, 渡部裕, 福原茂朋, 牧山武, 堀江稔, 萩原誠久, 望月直樹, Schott J-J. 家族性心臓伝導障害に同定されたconnexin 40遺伝子GJA5変異の機能異常. 心電図. 2010;30:267.
  3. 蒔田直昌. 病態に応じた循環器薬の使い方とコツ カルシウム拮抗薬 不整脈における使い方. Heart View. 2010;14:111-115. (pdf)
  4. 蒔田直昌. Brugada症候群の新潮流 Brugada症候群とその類縁疾患の病態. 心電図. 2010;30:S-4-130.
  5. 蒔田直昌. QT延長症候群をめぐる最近の話題 心電図QT時間の遺伝的素因. 心電図. 2010;30:S-4-126.
  6. 蒔田直昌. 心臓の微細構造異常と不整脈 Gap junctionと不整脈 遺伝子異常の観点から. 心臓. 2010;42:1126-1131. (pdf)
  7. 蒔田直昌. 不整脈研究の最先端 不整脈とイオンチャネル病. 医学のあゆみ. 2010;234:619-626. (pdf)
  8. 蒔田直昌. Brugada症候群およびその類縁疾患の基礎と臨床. 心臓. 2010;42:24.
  9. 蒔田直昌. 心臓突然死の予知と遺伝子検査. In: 相澤義房, ed. 心臓突然死. 大阪: 最新医学社; 2010:180-189. (pdf)

 

 <2009>

英文論文

  1. Sato A, Arimura T, Makita N, Ishikawa T, Aizawa Y, Ushinohama H, Aizawa Y, Kimura A. Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome. J Biol Chem. 284(50), 35122-33(2009) doi:10.1074/jbc.M109.017293. (pdf)
  2. Tsurugi T, Nagatomo T, Abe H, Oginosawa Y, Takemasa H, Kohno R, Makita N, Makielski JC, Otsuji Y. Differential modulation of late sodium current by protein kinase A in R1623Q mutant of LQT3. Life Sci. 2009;84:380-387. (PubMed: 19167409)
  3. Okishige K, Sugiyama K, Maeda M, Aoyagi H, Kurabayashi M, Miyagi N, Ueshima D, Azegami K, Takei T, Itoh T, Makita N. Aborted sudden death associated with short QT syndrome. Arrhythmia. 2009;25:214-218. (Science Direct) (pdf)
  4. Makita N. Phenotypic overlap of cardiac sodium channelopathies: individual-specific or mutation-specific? Circ J. 2009;73:810-817. (PubMed: 19336922)
  5. Kamakura S, Ohe T, Nakazawa K, Aizawa Y, Shimizu A, Horie M, Ogawa S, Okumura K, Tsuchihashi K, Sugi K, Makita N, Hagiwara N, Inoue H, Atarashi H, Aihara N, Shimizu W, Kurita T, Suyama K, Noda T, Satomi K, Okamura H, Tomoike H. Long-term prognosis of probands with Brugada-pattern ST-elevation in leads V1-V3. Circ Arrhythm Electrophysiol. 2009;2:495-503. (PubMed: 19843917)

 

和文論文

  1. 蒔田直昌, 住友直方, 関明子, 萩原誠久, 渡部裕, 福原茂朋, 望月直樹, 牧山武, 堀江稔, Schott J-J. 家族性進行性心臓伝導障害に同定されたconnexin40遺伝子GJA5変異の機能異常. 心電図. 2009;29:S-3-233.
  2. 蒔田直昌. 診る 難治性不整脈の遺伝子検査. Heart View. 2009;13:984-990. (pdf)
  3. 蒔田直昌. 心電学マイルストーン. 心電図. 2009;29:355. (pdf)
  4. 山形研一郎, 堀江稔, 赤尾昌治, 大江透, 草野研吾, 相澤義房, 山岸正和, 蒔田直昌, 小川聡, 田中敏博, 萩原誠久, 岸良示, 宮本恵宏, 鎌倉史郎, 清水渉. Brugada症候群におけるSCN5A遺伝子変異と臨床像 多施設登録による検討. 心電図. 2009;29:S-3-187.

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