Nagasaki U Link
Nagasaki University Graduate School of Biomedical Sciences 長崎大学学院医歯薬学総合研究科
 

辻 幸臣 講師

自己紹介

平成4年金沢大学医学部卒業、平成13年名古屋大学大学院医学系研究科修了、平成25年から本学に勤務しています。心臓突然死を引き起こす心室頻拍や心室細動などの致死性不整脈の発生機序を、細胞分子レベルで解明し、細胞内シグナル分子やその関連蛋白を標的とする新しい不整脈治療法の開発を目指しています。 (link to project)

学位

医師 (1992年3月 金沢大学医学部医学科 卒業)

医学博士(2001年3月 名古屋大学大学院医学系研究科 修了)

業績

  1. Tsuji Y, Dobrev D. “Prognostic impact of electrical storm in patients with implantable cardioverter defibrillators: mechanistic and therapeutic considerations to reduce the risk of death”. Int J Cardiol 2018; 255:101-102.
  2. Tsuji Y, Dobrev D. “Electrical storm: mechanistic and therapeutic considerations to avoid death in the survivors”. J Thorac Dis 2018; 10: S4053-S4056.
  3. Ishikawa T, Tsuji Y, Makita N. “Inherited Bradyarrhythmia: A Diverse Genetic Background”J Arrhythm. 2016;  32:352-358.
  4. Ishikawa T, Jou CJ, Nogami A, Kowase S, Arrington CB, Spencer M. Barnett SM, Harrell DT, Arimura T, Tsuji Y, Kimura A, Makita N. “A novel mutation in the α-myosin heavy chain gene is associated with sick sinus syndrome”Circ Arrhythm Electrophysiol.2015; 8: 400-408. (pdf) (PubMed: 25717017)
  5. Tsuji Y, Ishikawa T, Makita N. “Molecular mechanisms of heart failure progression associated with implantable cardioverter-defibrillator shocks for ventricular tachyarrhythmias”. J Arrhythmia. 2014;30:235-241.  (pdf)
  6. Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kaab S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL, Jr. “Novel calmodulin mutations associated with congenital arrhythmia susceptibility”.Circ Cardiovasc Genet 2014;7:466-474. (pdf) (PubMed: 24917665)
  7. Abe K, Machida T, Sumitomo N, Yamamoto H, Ohkubo K, Watanabe I, Makiyama T, Fukae S, Kohno M, Harrell DT, Ishikawa T, Tsuji Y, Nogami A, Watabe T, Oginosawa Y, Abe H, Maemura K, Motomura H, Makita N. “Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics”.Circ Arrhythm Electrophysiol.2014;7:511-517. (pdf) (PubMed: 24762805)
  8. Tsuji Y, Dobrev D. “Safety and efficacy of vernakalant for acute cardioversion of atrial fibrillation: an update”Vasc Health Risk Manag. 2013; 9:165-75.  (pdf) (PubMed: 23637539)
  9. Tsuji Y, Heijman J, Nattel S, Dobrev D. “Electrical storm: recent pathophysiological insights and therapeutic consequences”.  Basic Res Cardiol. 2013; 108:336.  (pdf) (PubMed: 23429935)
  10. Tsuji Y“Electrical storm and calcium signaling: a review”.  J Electrocardiol.2011; 44:725-729  (pdf) (PubMed: 22018487)
  11. Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K., “Ca2+-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm”. Circulation. 123: 2192-2203, 2011.  (pdf) (PubMed: 21555709)
  12. Qi XY, Yeh YH, Chartier D, Xiao L, Tsuji Y, Brundel BJJM, Kodama I, Nattel S. The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long QT Syndrome”Circ Arrhythmia Electrophysiol. 2009; 2:295-304.    (pdf) (PubMed: 19808480)

 

 

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