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Nagasaki University Graduate School of Biomedical Sciences 長崎大学学院医歯薬学総合研究科

Yukiomi Tsuji, Lecturer


I received my Medical Degree from Kanazawa University School of Medicine in 1992. Afterwards, my residency was done at Nagoya Daini Red Cross Hospital with a specialty in cardiology.  As a graduate student at Research Institute of Environmental Medicine(RiEM), Nagoya University, I began my research toward finding the mechanisms that cause lethal arrhythmias and the cause of sudden cardiac death.  My work has taken me to the Montreal Heart Institute in Canada, the Utrecht University Medical Center’s Department of Physiology in The Netherlands(Dr. Stanley Nattel), and Essen Duiburg University.  Most recently, I worked at University of Heidelberg Faculty of Medicine in Mannheim, Germany(Dr. Dobromir Dobrev). As ofApril 2013, I joined the the Department of Molecular Physiology, where I will use my previously established animal model to reproduce the pathology and cause of fatal and complicated ventricular arrhythmia such as electrical storms.(link to project)


  • MD (Kanazawa University School of Medicine ’92)
  • PhD in Medical Science(Nagoya University School Research Institute of Environment Medicine ’01)


  1. Ishikawa T, Tsuji Y, Makita N. “Inherited Bradyarrhythmia: A Diverse Genetic Background”J Arrhythm. 2015; (in press)
  2. Ishikawa T, Jou CJ, Nogami A, Kowase S, Arrington CB, Spencer M. Barnett SM, Harrell DT, Arimura T, Tsuji Y, Kimura A, Makita N. “A novel mutation in the α-myosin heavy chain gene is associated with sick sinus syndrome”Circ Arrhythm Electrophysiol.2015; 8: 400-408. (pdf) (PubMed: 25717017)
  3. Tsuji Y, Ishikawa T, Makita N. “Molecular mechanisms of heart failure progression associated with implantable cardioverter-defibrillator shocks for ventricular tachyarrhythmias”. J Arrhythmia. 2014;30:235-241.  (pdf)
  4. Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kaab S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL, Jr. “Novel calmodulin mutations associated with congenital arrhythmia susceptibility”.Circ Cardiovasc Genet 2014;7:466-474. (pdf) (PubMed: 24917665)
  5. Abe K, Machida T, Sumitomo N, Yamamoto H, Ohkubo K, Watanabe I, Makiyama T, Fukae S, Kohno M, Harrell DT, Ishikawa T, Tsuji Y, Nogami A, Watabe T, Oginosawa Y, Abe H, Maemura K, Motomura H, Makita N. “Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics”.Circ Arrhythm Electrophysiol.2014;7:511-517. (pdf) (PubMed: 24762805)
  6. Tsuji Y, Dobrev D. “Safety and efficacy of vernakalant for acute cardioversion of atrial fibrillation: an update”Vasc Health Risk Manag. 2013; 9:165-75.  (pdf) (PubMed: 23637539)
  7. Tsuji Y, Heijman J, Nattel S, Dobrev D. “Electrical storm: recent pathophysiological insights and therapeutic consequences”.  Basic Res Cardiol. 2013; 108:336.  (pdf) (PubMed: 23429935)
  8. Tsuji Y“Electrical storm and calcium signaling: a review”.  J Electrocardiol.2011; 44:725-729  (pdf) (PubMed: 22018487)
  9. Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K., “Ca2+-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm”. Circulation. 123: 2192-2203, 2011.  (pdf) (PubMed: 21555709)
  10. Qi XY, Yeh YH, Chartier D, Xiao L, Tsuji Y, Brundel BJJM, Kodama I, Nattel S. The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long QT Syndrome”Circ Arrhythmia Electrophysiol. 2009; 2:295-304.    (pdf) (PubMed: 19808480)



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