Nagasaki U Link
Nagasaki University Graduate School of Biomedical Sciences 長崎大学学院医歯薬学総合研究科

Yukiomi Tsuji, Senior Assistant Professor


I graduated from Kanazawa University School of Medicine in 1992. As a PhD student at Research Institute of Environmental Medicine, Nagoya University in 1998, I started with research projects about cardiac electrophysiology. My work had taken to the Montreal Heart Institute (Dr. Stanley Nattel) in Canada, and University of Duisburg-Essen and University of Heidelberg Medical Faculty Mannheim (Dr. Dobromir Dobrev) in Germany. Since 2013, I have joined the Department of Molecular Physiology, Nagasaki University. My current interest is to develop a new mechanism-based therapeutic approach for complicated ventricular tachyarrhythmias called electrical storm. (link to project)


MD (Kanazawa University School of Medicine ’92)

PhD in Medical Science (Nagoya University Graduate School of Medicine ’01)


  1. Tsuji Y, Dobrev D. “Prognostic impact of electrical storm in patients with implantable cardioverter defibrillators: mechanistic and therapeutic considerations to reduce the risk of death”. Int J Cardiol 2018; 255:101-102.
  2. Tsuji Y, Dobrev D. “Electrical storm: mechanistic and therapeutic considerations to avoid death in the survivors”. J Thorac Dis 2018; 10: S4053-S4056.
  3. Ishikawa T, Tsuji Y, Makita N. “Inherited Bradyarrhythmia: A Diverse Genetic Background”J Arrhythm 2016;  32:352-358.
  4. Ishikawa T, Jou CJ, Nogami A, Kowase S, Arrington CB, Spencer M. Barnett SM, Harrell DT, Arimura T, Tsuji Y, Kimura A, Makita N. “A novel mutation in the α-myosin heavy chain gene is associated with sick sinus syndrome”Circ Arrhythm Electrophysiol.2015; 8: 400-408. (pdf) (PubMed: 25717017)
  5. Tsuji Y, Ishikawa T, Makita N. “Molecular mechanisms of heart failure progression associated with implantable cardioverter-defibrillator shocks for ventricular tachyarrhythmias”. J Arrhythmia. 2014;30:235-241.  (pdf)
  6. Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kaab S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL, Jr. “Novel calmodulin mutations associated with congenital arrhythmia susceptibility”.Circ Cardiovasc Genet 2014;7:466-474. (pdf) (PubMed: 24917665)
  7. Abe K, Machida T, Sumitomo N, Yamamoto H, Ohkubo K, Watanabe I, Makiyama T, Fukae S, Kohno M, Harrell DT, Ishikawa T, Tsuji Y, Nogami A, Watabe T, Oginosawa Y, Abe H, Maemura K, Motomura H, Makita N. “Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics”.Circ Arrhythm Electrophysiol.2014;7:511-517. (pdf) (PubMed: 24762805)
  8. Tsuji Y, Dobrev D. “Safety and efficacy of vernakalant for acute cardioversion of atrial fibrillation: an update”Vasc Health Risk Manag. 2013; 9:165-75.  (pdf) (PubMed: 23637539)
  9. Tsuji Y, Heijman J, Nattel S, Dobrev D. “Electrical storm: recent pathophysiological insights and therapeutic consequences”.  Basic Res Cardiol. 2013; 108:336.  (pdf) (PubMed: 23429935)
  10. Tsuji Y“Electrical storm and calcium signaling: a review”.  J Electrocardiol.2011; 44:725-729  (pdf) (PubMed: 22018487)
  11. Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K., “Ca2+-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm”. Circulation. 123: 2192-2203, 2011.  (pdf) (PubMed: 21555709)
  12. Qi XY, Yeh YH, Chartier D, Xiao L, Tsuji Y, Brundel BJJM, Kodama I, Nattel S. The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long QT Syndrome”Circ Arrhythmia Electrophysiol. 2009; 2:295-304.    (pdf) (PubMed: 19808480)



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